Up to 85% of women who develop breast cancer have little to no family history of the disease
Hereditary Breast and Ovarian Cancer
Approximately 15% of women diagnosed with breast cancer have some type of family history of the disease. For this small percentage of women, there may be a very strong family history of breast cancer and other types or related cancers. This type of cancer develops when there is a change to certain genes that are passed down from a parent to his/her child. Women who have these genetic changes are at higher risk of developing something called Hereditary Breast and Ovarian Cancer (HBOC). It is important to identify these women so they can receive proper management and follow up from their healthcare providers and cancer prevention specialists.
Sporadic Breast Cancer
However, up to 85% of breast cancer cases do NOT develop due to an abnormal gene being passed down from a parent to his/her child. Instead, they are caused by a woman’s genetic makeup combined with environmental factors. This type of breast cancer is called sporadic breast cancer and often takes a woman by surprise. As this type of breast cancer often develops without warning, it becomes even more important to identify your risk factors. This will allow your healthcare provider to work with you on creating management plans that can reduce your risk of developing breast cancer.
- BREVAGenplus provides information about breast cancer risk over a 5 year period; it does not diagnose breast cancer
- BREVAGenplus is validated in African American, Caucasian, and Hispanic women age 35 years or older
- The risk estimate used in this test does not take into account several other breast cancer risk factors, such as an extensive family history of breast and ovarian cancer and thus does not provide a lifetime risk score
- This test is used for clinical purposes
* BREVAGenplus is not applicable to women who are already at high risk of breast cancer including those that have a personal or extensive family history of breast and/or ovarian cancer, LCIS, DCIS, AH or have thoracic RT under 30y. Any women with these risk factors are already at increased risk of breast cancer and should be screened and followed as such.
1. ACS, BREAST CANCER RISK AND PREVENTION; Accessed online July 2017; https://www.cancer.org/cancer/breast-cancer/risk-and-prevention/breast-cancer-risk-factors-you-cannot-change.html#references