BREVAGenplus combines Clinical Risk Factors and Genetic Markers to provide a personalized risk of developing breast cancer.
Clinical Risk Factors
There are certain Clinical Risk Factors that increase your patient’s risk of developing breast cancer. Some risk factors are within her control (such as diet and exercise), and some factors are outside of her control (such as being a woman, or her age). Age is the most significant risk factor associated with breast cancer, other than being female. The clinical risk factors included in BREVAGeplus are age and having first degree relatives with breast cancer (if any).
BREVAGenplus looks for differences in your patient’s DNA known as Single Nucleotide Polymorphisms (SNPs). Because certain SNPs are associated with breast cancer, analyzing them can help predict your patient’s chances of developing breast cancer over a 5 year period. The total risk from all SNPs analyzed in BREVAGenplus for a patient is referred to as her polygenic risk score. Your patient’s DNA is collected via a simple cheek swab that is performed at your office. If you are interested in this test, please contact us.
BREVAGenplus Integrated Risk Score
Integration of the polygenic risk score with the 3 most significant clinical risk factors (sex, age and 1st degree family history) can provide a more accurate 5 year risk score than these clinical factors alone and thus can guide clinical prevention and screening recommendations for a woman that is classified as increased risk by her 5 year risk score.
- BREVAGenplus provides information about breast cancer risk over a 5 year period; it does not diagnose breast cancer
- BREVAGenplus is validated in African American, Caucasian, and Hispanic women age 35 years or older
- The risk estimate used in this test does not take into account several other breast cancer risk factors, such as an extensive family history of breast and ovarian cancer and thus does not provide a lifetime risk score
- This test is used for clinical purposes
* BREVAGenplus is not applicable to women who are already at high risk of breast cancer including those that have a personal or extensive family history of breast and/or ovarian cancer, LCIS, DCIS, AH or have thoracic RT under 30y. Any women with these risk factors are already at increased risk of breast cancer and should be screened and followed as such.